spiermetabolisme Loss of muscle mass sarcopenia
Conditions
Interventions
one group (n=16) will consume a test beverage of 600 mL containing 20 g of
intrinsically labeled casein in water, and the other group (n=16) will consume
a beverage of the same volume containing 20
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Males - Aged between 65-85 years - Healthy, recreationally active (self-reported total of 2-4 hours of walking and/or light cycling (for transportation purposes) per week) - BMI
Exclusion criteria
Exclusion criteria: - Female - Smoking - Allergies to milk proteins (whey or casein) - Arthritic conditions - Over the counter antacids - Diabetes mellitus type 1 and type 2 (fasting blood glucose above 6.1 mmol/L and and/or 2 hour OGTT glucose level higher than 7.8 mmol/L) - A history of neuromuscular problems - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). - Participation in any structured regular exercise program - Chronic use of gastric acid suppressing medication or anti-coagulants - Unstable weight over the last three months - Pathologies of the gastrointestinal tract
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint: Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: Rate of protein digestion and absorption and whole body protein balance | — |
Countries
Netherlands
Outcome results
None listed