depressive disorder major depressive disorder
Conditions
Interventions
A computerized positivity training, based on cognitive bias modification (CBM)
for attention, is offered eight times during a period of two weeks (i.e., 4
weekly sessions), for 25 minutes per sessio
Sponsors
ProPersona (Nijmegen)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - A diagnosis of major depressive disorder, first or recurrent according to the DSM- IV-TR, as assessed with the MINI. - Wait-listed for Cognitive Behavioral Therapy - Age: between 21-65 years
Exclusion criteria
Exclusion criteria: - Any psychotic disorder (current or previous) - Current mania or hypomania or a history of bipolar disorder - Cognitive disabilities (IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameter is a change in attentional bias as assessed by the *dot probe task*. | — |
Secondary
| Measure | Time frame |
|---|---|
| Next to investigating training effect on changes in bias, understanding the impact of the intervention on depressive symptomatology, emotional vulnerability and quality of life is important from a clinical perspective, while assessing the cost-effectiveness is important from a societal perspective. For these secondary (i.e., more distal) outcomes, a probabilistic medical decision-making approach is taken. Secondary outcome measures are emotional vulnerability in response to a speech task and a decrease in depressive symptoms. Other secondary outcome measures are a change in attentional bias for verbal positive and negative information (*emotional Stroop task*), a change in positive imagery abilities, attentional control, ruminative thinking, resilience, positive and negative affect, memory bias, number of sessions of usual care, and quality of life and costs and diagnostic status at 12 months follow-up. | — |
Countries
Netherlands
Outcome results
None listed