Hemodialyse
Conditions
Interventions
Discontinuation of melatonin for 7 days
Sponsors
Meander Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Hemodialysis patients Age: 18-85 years Informed consent Good knowledge of dutch language Melatonine use for at least 12 weeks
Exclusion criteria
Exclusion criteria: Severe comorbidy such as heart failure class IV, instable AP, pulmonal, psychiatric or neurologic disease Blindness Nocturnal dialysis Documented sleep apnea Alcohol or drug abuse Use of hypnotics such as benzodiazepines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melatonin concentration measured in saliva versus time of day during 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Melatonin concentration measured in salvia, calculating area under the curve Change in baseline melatonin concentration (comparising melatonin concentration t=15:00 of 3 different days) Objective sleepparameters using actometer and the relation to melatonin kinetics. Subjective sleepscore using ESS questionaire and chronotype and the relation to melatonin kinetics. | — |
Countries
Netherlands
Outcome results
None listed