THE MORPHOLOGY OF THE BASEMENT MEMBRANE ZONE OF HAIR FOLLICLES IN HIDRADENITIS SUPPURATIVA: A PILOT STUDY

THE MORPHOLOGY OF THE BASEMENT MEMBRANE ZONE OF HAIR FOLLICLES IN HIDRADENITIS SUPPURATIVA: A PILOT STUDY - Morphology of the basal membrane zone in hidradenitis suppurativa

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40233

Enrollment

Registered

2014-03-11

Start date

2014-03-20

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acne ectopica acne inversa

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with HS who have been planned for surgical treatment of HS, aged 18-50 years.;Healthy volunteers with no skin diseases located in the armpits, aged 18-50 years

Exclusion criteria

Exclusion criteria: Lack of informed consent

Design outcomes

Primary

Measure	Time frame
To determine with direct immunofluorescence (DIF) whether there is a difference in expression of the BMZ components BP180, collagen type VII, laminine-332 and integrine*4 at the interfollicular epidermis and hair follicles between HS patients and healthy controls. Additionally, a PAS-staining of the skin samples will be performed to compare the degree of positivity between perilesional HS skin and normal skin from healthy controls. Finally, the morphology of the normal hair follicle localized on apocrine gland bearing skin will be described.	—

Measure

Time frame

To determine with direct immunofluorescence (DIF) whether there is a difference in expression of the BMZ components BP180, collagen type VII, laminine-332 and integrine*4 at the interfollicular epidermis and hair follicles between HS patients and healthy controls. Additionally, a PAS-staining of the skin samples will be performed to compare the degree of positivity between perilesional HS skin and normal skin from healthy controls. Finally, the morphology of the normal hair follicle localized on apocrine gland bearing skin will be described.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results