vitamin C deficiency
Conditions
Interventions
None listed
Sponsors
Dialyse Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Predialysis patients with minimal 3 months ECC = 30 ml/min PD patients: minimal 3 months peritoneal dialysis treatment CHD patients: 3 x per week 4 hours dialysis (± 12 hours dialysis per week), minimal 3 months hemodialysis treatment NCHD patients: every other night 8 hours dialysis (± 28 hours dialysis per week), minimal 3 months in nocturnal hemodialysis treatment
Exclusion criteria
Exclusion criteria: Malabsorption, gastro intestinal diseasese, oncological diseases, and absence of informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Predialysis patients: plasma vitamin C level; 2. NTx patients: plasma vitamin C level; 3. PD patients: plasma vitamin C level, 4. CHD patients: plasma vitamin C levels before, during and after dialysis; 5. NCHD patients: plasma vitamin C levels before, during and after dialysis. In all groups vitamin C intake will be assessed using a 24-hour recall questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| CHD (3 dialysate measurements), - vitamin C measurements from the dialysate: 15 minutes after start dialysis, after 2 hours dialysis, and 15 minutes before the end of the dialysis treatment. - total Kt/V (dialysis efficiency). NCHD (4 dialysate measurements), - vitamin C measurements from the dialysate: 15 minutes after start dialysis, after 3 hours dialysis, after 6 hours dialysis, and 15 minutes before the end of the dialysis treatment. - total Kt/V (dialysis effciency). Laboratory measurements: Hemoglobin, sodium, potassium, urea, creatinine, alkaline phosphatase, calcium, phosphate, albumin, ferritin, TSAT, CRP, PTH (standard monthly measurements) | — |
Countries
Netherlands
Outcome results
None listed