Linking the periphery with the CNS: Do pupil dilation and skin conductance responses correlate with locus coeruleus and amygdala activity?

Linking the periphery with the CNS: Do pupil dilation and skin conductance responses correlate with locus coeruleus and amygdala activity? - Linking the periphery with the CNS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40221

Enrollment

Registered

2013-08-02

Start date

2014-04-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

scientific investigation of healthy subjects healthy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy adult subjects with no history of neurological disorder/disease and no counter-indications to 3 and 7 Tesla MRI. All participants will be right-handed with normal vision or contact lenses.

Exclusion criteria

Exclusion criteria: Potential participants will be pre-screened for contra-indications for 3 and 7 Tesla fMRI, which include metal implants, heart arrhythmia, claustrophobia, and possible pregnancy (in adult females). They will additionally be pre-screened for head trauma, premature birth, learning disabilities, and history of neurological or psychiatric illness and/or use of psychotropic medications. Finally, left-handed individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.

Design outcomes

Primary

Measure	Time frame
MRI will be performed at the 3T and at the 7T (for the session 4) scanner located in the radiology department of the LUMC. A specific high-resolution scan sequence, developed for visualizing the brainstem, will be carried out and used for subsequent localization of the fMRI images. Functional images will be acquired with a high-resolution EPI sequence, centered on the brainstem. Simultaneously, pupil diameter will be measured using an EyeLink 1000 fMRI-compatible eye tracker and skin conductance and heart rate will be measured with an MRI-compatible MP150 BIOPAC recording device (BIOPAC systems Inc.).	—

Measure

Time frame

MRI will be performed at the 3T and at the 7T (for the session 4) scanner located in the radiology department of the LUMC. A specific high-resolution scan sequence, developed for visualizing the brainstem, will be carried out and used for subsequent localization of the fMRI images. Functional images will be acquired with a high-resolution EPI sequence, centered on the brainstem. Simultaneously, pupil diameter will be measured using an EyeLink 1000 fMRI-compatible eye tracker and skin conductance and heart rate will be measured with an MRI-compatible MP150 BIOPAC recording device (BIOPAC systems Inc.).

—

Secondary

Measure	Time frame
Saliva will be collected at the beginning of the experimental session for genetic and cortisol analysis. Personality questionnaire measures will be administered to investigate whether the results are mediated by personality factors and mood questionnaire scores will be analyzed to investigate task effects on mood.	—

Countries

Netherlands

Outcome results