Tourette's disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: ONSET Study: 1. First degree relative of person with TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association) 2. Aged 3-10 years, male or female COURSE STUDY: 1. Having TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association) 2. Age 3-16 years, male or female;Parents and patients have provided written informed consent and assent as appropriate according to ethical regulation
Exclusion criteria
Exclusion criteria: ONSET: 1. Presence of tics 2. Presence of OCD 3. Serious medical illness 4. Child treated with antibiotics in the past 1 month. 5. Children and/or parents are unable to understand and comply with protocol. COURSE: 1. Serious medical illness 2. Child treated with antibiotics in the past 1 month. 3. Children and/or parents are unable to understand and comply with protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcome is onset of tics (ONSET study) and tic exacerbations (COURSE study), as assessed by the Yale Global tic severity scale (YGTSS) plus Premonitory Urge for Tics Scale (PUTS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Other main parameters are the presence of obsessive-compulsive symptoms as assessed by the Children*s Yale Brown Obsessive-Compulsive Scale (CY-BOCS) and the presence of GAS in throat swabs. | — |
Countries
Netherlands
Outcome results
None listed