algehele gezondheid, metabole gezondheid abdominal fat Fatty liver
Conditions
Interventions
Allocation to one of the two designed dietary advices, counselling by
professional dieticians.
Both diets are based on a caloric restriction of 30%.
(1) Dietary advice based on a more Western diet
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age 40-70y at the time of recruitment BMI >27kg/m2 or waist circumference >102cm (males) or >88cm (females)
Exclusion criteria
Exclusion criteria: Hb levels 30g (men) or >20g (women) Tobacco smoker Abuse of drugs Any medical conditions or (metal) devices interfering with or posing a risk for the participant in 1H-MRS/MRI scanning (e.g. claustrophobia, pace maker, surgical screws/pins, artificial joints or heart valves, etc.) Diagnosed with any long-term medical condition (i.e. cardiovascular disease, gastrointestinal disease, renal dysfunction) Use of medications known to interfere with glucose or lipid homeostasis (i.e. corticosteroids) Allergic to fish oil or unwilling to consume fish oil supplements Unwilling to comply with dietary guidelines Restricted to a vegetarian dietary regime
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid accumulation in the liver (MRS) Body fat distribution (MRI) Physical fitness (VO2 max in a maximal exercise test) After a challenge meal: Metabolic plasma markers (cardio-metabolic risk factors, gut function, adipose tissue and muscle health) Peripheral blood mononuclear cells (gene expression patterns) Satiety and well-being (questionnaires) Adipose tissue en muscle biopsies (genome/epigenome determinations) Vascular functions (vascular health, blood pressure, aterial stiffness) | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain activity (fMRI) Olfactory test Questionnaire on food preferences | — |
Countries
Netherlands
Outcome results
None listed