Prospective, single-center study of the effect on NT-proBNP levels of maintaining sinus rhythm after elective electrical cardioversion for persistent atrial fibrillation in patients with chronic heart failure and ejection fraction < 35%

Prospective, single-center study of the effect on NT-proBNP levels of maintaining sinus rhythm after elective electrical cardioversion for persistent atrial fibrillation in patients with chronic heart failure and ejection fraction < 35% - ECV-HF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40197

Enrollment

Registered

2013-05-02

Start date

2013-05-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation chronic heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosis of chronic heart failure with reduced ejection fraction (

Exclusion criteria

Exclusion criteria: 1. Hospitalization for heart failure in the previous 3 months before inclusion for another reason than for AF,. 2. Patients undergoing Continue Ambulant Peritoneal Dialysis (CAPD)/ Haemodialysis 3. Patient with a ST-segment-Elevated Myocardial Infarction (STEMI), CABG, PCI, CRT and/or valvular surgery within 1 month prior to ECV 4. Patients with planned Coronary Artery Bypass Grafting (CABG), Percutaneous Coronary Intervention (PCI), Cardiac Resynchronization Therapy (CRT) and/or valvular surgery in the month after electrocardioversion. 5. Documented recurrence of AF of more than 24 hours per week in the last two weeks (or extended period) of follow-up. 6. Worsening of heart failure requiring hospitalization or visit to the emergency room for other reasons than for AF during the first two weeks, and for any reason during the third to sixth week of study period. 7. Spontaneous (documented) conversion to sinus rhythm before ECV. 8. Signed informed consent for any current interventional study.

Design outcomes

Primary

Measure	Time frame
Significant reduction in NT-proBNP levels after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction	—

Secondary

Measure	Time frame
- Significant reduction in NT-proBNP levels after electrical cardioversion for persistent AF in patients with severe chronic heart failure and reduced ejection fraction compared to patients with persistent AF and normal heart function.- - Significant change in cardiac output after ECV - Significant change in serum aldosterone levels after ECV	—

Countries

Netherlands

Outcome results