arterial wall thickening atherosclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group A: 40 Healty control subjects - Aged 18 years or older;Group B: 40 Chronic kidney disease (CKD) patients - Aged 18 years or older - 20 CKD stages 3 and 4 (GFR: 15-60 ml min-1) and - 20 Kidney transplant donors with GFR: 15-60 ml min-1 for a duration of at least 3 months - Non inflamed (CRP
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects - Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. - Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. - Clinical signs of acute infection and/or CRP>10;Exclusion criteria for group B: Chronic Kidney Disease - Diabetic nephropathy - History of MI/Stroke;Exclusion criteria for group C: Rheumatoid artitis - History of MI/Stroke;Exclusion criteria for group D: Peripheral artery disease - MI/Stroke in the last 12 months;Exclusion criteria for group E: Hypercholesterolemia - MI/Stroke in the last 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the trans endothelial migration capability and subtyping of monocytes in relation to underlying disease (activity). | — |
Secondary
| Measure | Time frame |
|---|---|
| Other important study parameters include epigenetic changes of monocytes and differences in cytokine production after stimuli. | — |
Countries
Netherlands
Outcome results
None listed