Obesity
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - * 18 years of age - Mentally able/allowed to give informed consent
Exclusion criteria
Exclusion criteria: See pages 16 and 17 of the researchprotocol. - Severe cardiopulmonary disease (as stated in the SOP Exercise testing) - Orthopedic and/or neurological diseases that impair exercise (as stated in the SOP Exercise testing) - Anticoagulant therapy (i.e. acenocoumarol, marcoumar) - Lidocaine allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main outcome parameter is fat endocrine function (i.e. fat biopsy and subsequent analysis of expression level of adipokines, and measurement of circulating adipokine levels). For aim 2, we will also examine metabolic function (glucose and insulin levels) and cardiovascular function (brachial artery flow-mediated dilation, carotid intima-media thickness). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters relate to body composition (fat percentage+distribution), physical activity level (measured using an activity monitor), maximal oxygen consumption (measured as peak oxygen consumption during an incremental cycling test), and traditional biomarkers in blood for metabolic and cardiovascular risk (e.g. cholesterol, hs-CRP, HbA1c). | — |
Countries
Netherlands
Outcome results
None listed