The relation between cerebral blood flow, pain attenuation and autonomic parameters in rest, during and after exercise in patients with the chronic fatigue syndrome.

The relation between cerebral blood flow, pain attenuation and autonomic parameters in rest, during and after exercise in patients with the chronic fatigue syndrome. - Cerebral blood flow, pain and chronic fatigue syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40186

Enrollment

102

Registered

2014-03-19

Start date

2014-10-06

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronisch vermoeidheidssyndroom chronic fatigue syndrome myalgic encephalitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: CFS patients within the range of 18-65 years of age, who are diagnosed according to the Centre of Disease Control criteria Before being asked to participate to the study, the International Physical Questionnaire *short form, Dutch version- will be sent to potential candidates. Only those with categorical score: *low* will be asked to participate.

Exclusion criteria

Exclusion criteria: - Pregnancy or being postnatal within 1 year. - - The current use of opioid medication. - BMI >30. - Unable to perform a maximal exercise test. - Diabetes mellitus. - Medical condition leading to chronic pain in sedentary controls. - Suspicion of ischaemic complaints, regional wall motion abnormality or moderate to severe valvular disease.

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is the relationship between decreased cerebral blood flow during exercise and increased pain sensation after exercise.	—

Secondary

Measure	Time frame
Secondary Outcomes: - Cerebral blood flow before and after tilt table testing - Comparison of CBF changes between exercise and tilt table testing - Comparison of CBF changes between patients and healthy subjects - Comparison of PPT between patients and healthy subjects - Comparison of peak oxygen consumption between patients and healthy subjects - Relation of CBF and an increase in oxygen consumption during exercise. - Comparison of Vasalva maneuver measurements between patients and healthy subjects - Comparison of questionnaires between patients and healthy subjects.	—

Measure

Time frame

Secondary Outcomes: - Cerebral blood flow before and after tilt table testing - Comparison of CBF changes between exercise and tilt table testing - Comparison of CBF changes between patients and healthy subjects - Comparison of PPT between patients and healthy subjects - Comparison of peak oxygen consumption between patients and healthy subjects - Relation of CBF and an increase in oxygen consumption during exercise. - Comparison of Vasalva maneuver measurements between patients and healthy subjects - Comparison of questionnaires between patients and healthy subjects.

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Countries

Netherlands

Outcome results