In vitro investigation into the potential regulating role of sphingolipids in lymphocyte proliferation.

In vitro investigation into the potential regulating role of sphingolipids in lymphocyte proliferation. - Role of sphingolipids in lymphocyte function

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40165

Enrollment

Registered

2014-02-19

Start date

2014-03-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

not applicable

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must be at the age between 18 and 65 years old.

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: clinically relevant infection or inflammation, malignancy, any systemic disease, pregnancy.

Design outcomes

Primary

Measure	Time frame
The main study parameter is the in vitro proliferation rate of lymphocytes, measured as the number of cells, after 72 hours of incubation with specific agonists or antagonists for the sphingosine-receptors and substrates or blockers of the sphingosine-kinase and -transporter (i.e. the ABC C1-transporter).	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results