Practical biomarkers for the early detection of dementia

Practical biomarkers for the early detection of dementia - Practical Dementia Biomarkers

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40141

Enrollment

210

Registered

2014-02-04

Start date

2014-03-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia memory problems

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 50+ Memory complaints

Exclusion criteria

Exclusion criteria: Mental or legal incapacity to give informed consent. Major neurological and psychological defects (such as Parkinson's Disease, depression, etc.), age =

Design outcomes

Primary

Measure	Time frame
Cognitive tests: -Total scores and subscores of the TYM test and the MMSE test in subjects with memory complaints in comparison to subjects without memory complaints Specificity, sensitivity, positive predictive value and negative predictive value of the TYM and MMSE test General Health tests EEG: Amplitude and latency of P300 values in subjects with memory complaints as compared to subjects without memory complaints during an oddball test. Amplitude and latency of N400 values in subjects with memory complaints as compared to subjects without memory complaints during a linguistic test with semantic variables. Amplitude and latency of P600 values in subjects with memory complaints as compared to subjects without memory complaints during a linguistic tast with syntactic variables. Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned variables. Bloodmarkers: Variation in lymfocytic subsets and phenotype in subjects with memory complaints as compared to subjects without memory complaints . Variation in dendritic cell differentiation in subjects with memory complaints as compared to subjects without memory complaints. Cytokine expression patterns in subjects with memory complaints as compared to subjects without memory complaints. Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned immunological variables. Scores on lihfe style: including psysical activity, food intake and sleep quality Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned life style variables.	—

Measure

Time frame

Cognitive tests: -Total scores and subscores of the TYM test and the MMSE test in subjects with memory complaints in comparison to subjects without memory complaints Specificity, sensitivity, positive predictive value and negative predictive value of the TYM and MMSE test General Health tests EEG: Amplitude and latency of P300 values in subjects with memory complaints as compared to subjects without memory complaints during an oddball test. Amplitude and latency of N400 values in subjects with memory complaints as compared to subjects without memory complaints during a linguistic test with semantic variables. Amplitude and latency of P600 values in subjects with memory complaints as compared to subjects without memory complaints during a linguistic tast with syntactic variables. Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned variables. Bloodmarkers: Variation in lymfocytic subsets and phenotype in subjects with memory complaints as compared to subjects without memory complaints . Variation in dendritic cell differentiation in subjects with memory complaints as compared to subjects without memory complaints. Cytokine expression patterns in subjects with memory complaints as compared to subjects without memory complaints. Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned immunological variables. Scores on lihfe style: including psysical activity, food intake and sleep quality Specificity, sensitivity, positive predictive value and negative predictive value of the above mentioned life style variables.

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Secondary

Measure	Time frame
Insight in compliance of patients with memory complaints to advice/medication from the specialist. Insight in user-friendliness and accessibility of the cognitive tests, the EEG and the blood sampling procedure.	—

Countries

Netherlands

Outcome results