Sublingual microvascular changes in perfused vessel density and boundary region during an intravenous fluid challenge.

Sublingual microvascular changes in perfused vessel density and boundary region during an intravenous fluid challenge. - CHALLENGE study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40124

Enrollment

Registered

2013-07-25

Start date

2014-05-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Volumebelasting Perioperative fluid load

Interventions

In healthy subjects, the intervention includes two fluid boluses (crystalloid and colloid) of 300 ml each.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy subjects * Age 18-85 years * Normal renal function * Normal liver function Patients * Age 18-85 years * Normal renal function * Normal liver function

Exclusion criteria

Exclusion criteria: Healthy subjects * Peripheral edema * Cardiovascular disease (hypertension, myocardial ischemia, heart failure) * Use of antihypertensive, diuretics * Allergy to gelatines * Severe asthma;Patients * Peripheral edema * Myocardial infarction, heart failure, renal replacement therapy * Use of diuretics * Previous chemotherapy * Diabetes mellitus I or II with use of anti-diabetic medication * User of steroids

Design outcomes

Primary

Measure	Time frame
Microcirculatory perfused vessel density (PVD) and perfused boundary region (PBR) measured using sublingual capillary videoscope imaging.	—

Secondary

Measure	Time frame
* Intraoperative administered fluid volume, fluid balance, urine output * Microvascular Flow Index (MFI) * Microvascular flow heterogeneity * Hemodynamic parameters (blood pressure, heart frequency, pulse pressure variation in mechanically ventilated patients, stroke volume, cardiac index.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)