Sinusoidal Compared With Constant Work Rate High Intensity Exercise Training In COPD Patients With Ventilatory Limitation

Sinusoidal Compared With Constant Work Rate High Intensity Exercise Training In COPD Patients With Ventilatory Limitation - Sinusoidal exercise training in COPD.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40122

Enrollment

Registered

2013-12-16

Start date

2013-12-15

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Interventions

The two training programs contain exercise sessions of 45 minutes each, 3 days a week for 4 weeks. After the 4 week training program, the exercise tests performed in the assessment week will be repe

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: COPD GOLD II-IV A minimum of 40 Watts will be required as peak work rate.

Exclusion criteria

Exclusion criteria: Patients in the active phase of pulmonary rehabilitation involving exercise training and those participating in the past 18 months will be excluded. Cardiovascular comorbidity that constitutes a relative contraindication to a vigorous exercise program (for example recent myocardial infacrtion, ventricular arythmias)

Design outcomes

Primary

Measure	Time frame
The primary outcome measure will be comparison of improvement in endurance of a work rate initially eliciting exercise limitation after 6 minutes (calculated from the power-duration relationship before and after training). The power-duration plots of work rate vs. 1/tlim before and after training will be analyzed. The pre-training relationship will be interpolated to determine the work rate that would be tolerated for 6 minutes. The post-training power-duration relationship will be interpolated to determine the duration of exercise (tpost) at that work rate. The difference (tpost-6) represents the exercise training-induced increase in exercise duration. Using this derived measure of increased exercise endurance has the following advantages: 1) It utilizes all 4 pairs of exercise tests, increasing reliability over use of a single pair of exercise tests and 2) as the increase in exercise endurance is a strong function of the initial exercise duration, utilizing a fixed initial duration (6 minutes) will reduce the variance in exercise duration increase among subjects.	—

Measure

Time frame

The primary outcome measure will be comparison of improvement in endurance of a work rate initially eliciting exercise limitation after 6 minutes (calculated from the power-duration relationship before and after training). The power-duration plots of work rate vs. 1/tlim before and after training will be analyzed. The pre-training relationship will be interpolated to determine the work rate that would be tolerated for 6 minutes. The post-training power-duration relationship will be interpolated to determine the duration of exercise (tpost) at that work rate. The difference (tpost-6) represents the exercise training-induced increase in exercise duration. Using this derived measure of increased exercise endurance has the following advantages: 1) It utilizes all 4 pairs of exercise tests, increasing reliability over use of a single pair of exercise tests and 2) as the increase in exercise endurance is a strong function of the initial exercise duration, utilizing a fixed initial duration (6 minutes) will reduce the variance in exercise duration increase among subjects.

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Secondary

Measure	Time frame
Secondary outcome measures will include: * Change in critical power of the power-duration curve * Change in curvature constant of the power-duration curve * Change in iso-time ventilatory, gas exchange and heart rate responses and in dyspnea rating in the constant work rate tests * Change in peak VO2 and lactate threshold in the incremental exercise test * Change in 1RM of the leg press as a measure of leg strength	—

Measure

Time frame

Secondary outcome measures will include: * Change in critical power of the power-duration curve * Change in curvature constant of the power-duration curve * Change in iso-time ventilatory, gas exchange and heart rate responses and in dyspnea rating in the constant work rate tests * Change in peak VO2 and lactate threshold in the incremental exercise test * Change in 1RM of the leg press as a measure of leg strength

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)