asthma atopic dermatitis dermatitis
Conditions
Interventions
Before the start of the study:
All children will be treated by a dermatologist and a dermatology nurse in two
or three consultations in the WKZ/UMC Utrecht. Besides: all children have
access to the
Sponsors
dermatologi'/allergologie
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: - severe atopic dermatitis (atopy syndrome); children who still need intensive multidisciplinary care after fulfilling the usual 2 or 3 consultations with the dermatologist and dermatology nurse - 8-18 years - able to speak and write in Dutch - internet access and able to use the digital eczema centre Utrecht -willingness for a stay of 6 weeks in the Dutch Asthma Centre Davos
Exclusion criteria
Exclusion criteria: - Participation in study 08-368; However, children and their parents can be asked to participate in this study after finishing study 08-368
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomes for psychosocial study part are Coping and acceptance of the disease by the child. Primary outcome of clinical part of the study is disease activity of atopic dermatitis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Child: : - severity of asthma - self-esteem and feelings of competency - autonomy (for children of 12 years up) - anxiety - asthma -specific quality of life Parents: - stress - anxiety - disease-specific quality of life Secundary study parameters that will be investigated in the translational study: - FeNO (NO in exhaled air) - Eosinophils - Total IgE - Specific IgE to (auto)-allergens - NO (nitric oxide) in serum - Profile of Th1 and Th2 cytokines in serum - OPN (osteopontin) in serum - TSLP (thymic stromal lymphopoietin) in serum - TSLP and protease activity in the superficial skin - Bacterial colonization of the skin - TSLP DNA polymorphism Secundary parameters in this second amendement: - Bacterial colonization of the nose - Filaggrin mutations | — |
Countries
Netherlands
Outcome results
None listed