Geen aandoening als zodanig, gezonde participanten worden onderzocht. Not applicable
Conditions
Interventions
Stress induced through a transient psychological stressor in the form of a
digital game.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age 18-65, male or female Normal or corrected-to-normal vision
Exclusion criteria
Exclusion criteria: - Drug or alcohol abuse over a period of six months prior to the experiment - Unwillingness to view or hear aversive stimuli from the IAPS or IADS - Previously diagnosed with, or under treatment for, psychological or psychiatric disorders (e.g. depression, schizophrenia, neuroticism, etc.). - Previously diagnosed with, or under treatment for, medical indications (e.g. closed- or open-head injury, neurological illness, epilepsy, PTSD, cardiovascular indications, endocrinological dysfunction, etc.). - Use of medication (chronic/recently) - Pregnancy - Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) - Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study 1 The measured physiological stress responses (heart rate, systolic and diastolic blood pressure and electrodermal response) and cortisol response during all tasks. Study 2 The amplitude of the P300 and Feedback Related Negativity (FRN) component in response to both positive and negative feedback in the BART task during different stressor intensities. Study 3 The BOLD response in the striatum, anterior cingulate cortex, insula, dorsolateral and ventromedial prefrontal cortex, amygdala, and orbitofrontal cortex in response to positive and negative feedback and during decision-making, during different stressor intensities, during all BART trials. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed