The present proposal contains three separate research questions with a different background that both will be an extension of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER). Study 1: The relations between early childhood obesity and arterial disease. Study 2: Low lung function in early childhood: nature or nurture? Study 3: The relation between Diabetes type I during pregnancy and vascular characteristics in the offspring.

The present proposal contains three separate research questions with a different background that both will be an extension of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER). Study 1: The relations between early childhood obesity and arterial disease. Study 2: Low lung function in early childhood: nature or nurture? Study 3: The relation between Diabetes type I during pregnancy and vascular characteristics in the offspring. - WHISTLER/ Cardio

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40078

Enrollment

1000

Registered

2007-01-16

Start date

2007-06-05

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovasculaire ziekten en overgewicht Study 1 and 3: cardiovascular diseases. Study 2: asthma.

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Four- to six-year-old children who are willing and able to undergo the procedures described in the protocol and who*s parents have given written informed consent. For study 3, 7 to 10 year olds who are willing and able to undergo the procedures described in the protocol and who's parents have given written informed consent will be invited.

Exclusion criteria

Exclusion criteria: No exclusion criteria. For study 3: children who's mother had Diabetes gravidarum or Diabetes type II during pregnancy will be excluded.

Design outcomes

Primary

Measure	Time frame
The primary measured study parameters include obesity related measurements which comprises of anthropometry (body weight, height) and collection of nutritional data. Sonographic abdominal fat will be measured using ultrasound. The vascular conditions will be determined distension and intima-media thickness of the carotid artery as marker of preclinical atherosclerosis, measured using ultrasound. Furthermore blood pressure will be measured. To gain information about the respiratory system we will re-assess lung function (MicroRint and flow-volume measurements) and measure Nitric Oxide in exhaled air. Current clinical status will be obtained. Primary outcome in study 3 are the vascular parameters: carotid intima media thickness and vascular stiffness.	—

Measure

Time frame

The primary measured study parameters include obesity related measurements which comprises of anthropometry (body weight, height) and collection of nutritional data. Sonographic abdominal fat will be measured using ultrasound. The vascular conditions will be determined distension and intima-media thickness of the carotid artery as marker of preclinical atherosclerosis, measured using ultrasound. Furthermore blood pressure will be measured. To gain information about the respiratory system we will re-assess lung function (MicroRint and flow-volume measurements) and measure Nitric Oxide in exhaled air. Current clinical status will be obtained. Primary outcome in study 3 are the vascular parameters: carotid intima media thickness and vascular stiffness.

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Secondary

Measure	Time frame
None	—

Countries

Netherlands

Outcome results