Using patient-derived neurons to investigate the molecular and cellular basis of Major Depressive Disorder

Using patient-derived neurons to investigate the molecular and cellular basis of Major Depressive Disorder - Molecular basis of MDD/ MolMDD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40060

Enrollment

Registered

2013-03-18

Start date

2013-07-09

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression Major depressive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: A. Inclusion criteria for probands: 1. All subjects must give signed, informed consent. 2. Probands must have a DSM-IV consensus diagnosis of Major depressive disorder (MDD) or mood disorder with psychotic features. 3. Patients must have a positive outcome of Dexamethasone suppression test (DST): >=5 microgram/dl. 4. When age >= 65, the first depressive episode must have been before the age of 65. 5. Subjects must be over 18 years of age at interview, male or female.;B Inclusion criteria for healthy family members of probands: 1. First-, second-, or third degree biological family member of participating probands. As for the probands, family members must give signed, informed consent and be over 18 years of age at interview. 2. Healthy family members must have a negative outcome of Dexamethasone suppression test (DST):

Exclusion criteria

Exclusion criteria: A Exclusion criteria for probands: 1. Unable to give informed consent to all aspects of the study. 2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews). 3. The depressive disorder is deemed secondary to causative factors, such as medication, general medical condition or substance use. 4. Severe neurological diseases, or other severe co-morbid psychiatric disorders. 5. Pregnancy.;B Exclusion criteria for healthy family members of probands: 1. Unable to give informed consent to all aspects of the study. 2. Unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews). 3. Unwilling to be informed about accidental findings such as aberrant cortisol levels (800 nmol/l, source NKVC) or aberrant outcome of the other assessments. 4. Severe medical illness, substance abuse, or co-morbid psychiatric disorders. 5. Pregnancy.

Design outcomes

Primary

Measure	Time frame
1. Outcome of DST measurements 2. Biological variables tested in iPS derived neural cells of patients and control individuals.	—

Countries

Netherlands

Outcome results