(Toxic) Multinodular Goiter
Conditions
Interventions
no intervention
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Informed consent form signed * Age 18 years and over * Multinodular goiter, confirmed with thyroid ultrasound * Subclinical hyperthyroidism, defined as TSH
Exclusion criteria
Exclusion criteria: * Current use of antithyroid drugs * Treatment with radioactive iodine in history * Pregnancy. This condition may lead to subtle enlargement of the thyroid gland, secondary to iodine deficiency. All premenopausal female participants will undergo a *-hCG-urine test before inclusion. * Born and raised in iodine deficient areas, defined as the green and dark green fields in Figure 3 (protocol, p 13) . * Any medication known to interfere with thyroid hormone metabolism or with the study medication, like amiodarone, beta blockers, neuroleptics, corticosteroids including inhalation steroids, antihistaminics * Any condition that the investigator feels would interfere with trial participation or evaluation of results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endpoint The % increase in total T4, T3 and Free T4, defined as: ([T4/T3/FT4 max * T4/T3/FT4 at baseline]/ T4/T3/FT4 at baseline) x 100% | — |
Secondary
| Measure | Time frame |
|---|---|
| none reported | — |
Countries
Netherlands
Outcome results
None listed