Activation of Brown Adipose Tissue in Old and Young Individuals

Activation of Brown Adipose Tissue in Old and Young Individuals - Activation of Brown Adipose Tissue and Age

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39994

Enrollment

Registered

2013-02-21

Start date

2013-04-09

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Overweight and age

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male Caucasian Origin 18-65 years old BMI range 19-27kg/m2 Subjects should be able and willing to give informed consent

Exclusion criteria

Exclusion criteria: Renal failure (creatinine >135 mmol/L) Daily use of prescription medicine Prior participation in a research protocol involving radiation exposure in the last 2 years

Design outcomes

Primary

Measure	Time frame
Difference in semi quantitative uptake value of the tracer MIBG visualised with SPECT-CT in BAT (younger versus older individuals).	—

Secondary

Measure	Time frame
The correlation between semi-quantitative uptake of MIBG and SUV of FDG in young and older individuals will be calculated with a Pearson correlation coefficient. P-values for the difference in resting energy expenditure during thermoneutral conditions and during mild cold-exposure will be calculated with independent sample t-tests. Subsequently, the correlation between this difference in resting energy expenditure and the sympathetic stimulation of BAT as assessed with MIBG (and with metabolic BAT activity as assessed with FDG), will be calculated with a Pearson correlation coefficient. The correlation between insulin resistance in different age groups, and semi-quantitative uptake of MIBG, or SUV of FDG will be calculated with a Pearson correlation coefficient In view of the limited size of the study, no multivariate analyses will be performed.	—

Measure

Time frame

The correlation between semi-quantitative uptake of MIBG and SUV of FDG in young and older individuals will be calculated with a Pearson correlation coefficient. P-values for the difference in resting energy expenditure during thermoneutral conditions and during mild cold-exposure will be calculated with independent sample t-tests. Subsequently, the correlation between this difference in resting energy expenditure and the sympathetic stimulation of BAT as assessed with MIBG (and with metabolic BAT activity as assessed with FDG), will be calculated with a Pearson correlation coefficient. The correlation between insulin resistance in different age groups, and semi-quantitative uptake of MIBG, or SUV of FDG will be calculated with a Pearson correlation coefficient In view of the limited size of the study, no multivariate analyses will be performed.

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Countries

Netherlands

Outcome results