Study on IgE Memory B cells in Allergic disease

Study on IgE Memory B cells in Allergic disease - SIMBA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39979

Enrollment

180

Registered

2012-10-10

Start date

2013-01-22

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergy type I hypersensitivity responses

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: * children from 6-18 yrs old with asthma/rhinitis, atopic dermatitis or food allergy * Atopy with proven allergen (RAST class >1.4 or specific IgE serum levels > 0.7 IU/L or positive skin prick test with HEP index > 0.21) * Positive doubleblind food provocation test or convincing history of recent adverse response to food intake * Informed written consent

Exclusion criteria

Exclusion criteria: - Patients

Design outcomes

Primary

Measure	Time frame
From each patient, the absolute B- and T-cell numbers in blood (cells per milliliter of blood) will be determined, as well as the relative frequencies of naïve and IgM+, IgG+, IgA+ and IgE+ memory B-cells. Total and allergen-specific serum IgE levels will be determined. These parameters will be compared between patients with food allergy, patients with asthma, patients with hay fever and healthy controls. Finally, we will study the correlation of IgE+ memory-B-cell numbers with serum IgE levels and the IgE allergen-specificity.	—

Measure

Time frame

From each patient, the absolute B- and T-cell numbers in blood (cells per milliliter of blood) will be determined, as well as the relative frequencies of naïve and IgM+, IgG+, IgA+ and IgE+ memory B-cells. Total and allergen-specific serum IgE levels will be determined. These parameters will be compared between patients with food allergy, patients with asthma, patients with hay fever and healthy controls. Finally, we will study the correlation of IgE+ memory-B-cell numbers with serum IgE levels and the IgE allergen-specificity.

—

Secondary

Measure	Time frame
Relate the changes in the B-cell compartment and serum IgE levels to changes in T-cell subsets, eosinophils, basophils and mast cells in blood. Since the anatomical location differs between asthma/hay fever, atopic dermatitis and food allergy, we hypothesize that distinct B cells are involved.	—

Countries

Netherlands

Outcome results