Metabolic effects of morning light

Metabolic effects of morning light - SUNRISE

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39953

Enrollment

Registered

2013-01-11

Start date

2013-03-11

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

Subjects enter the facility in the evening. They will remain in normal room light (100-200 lux) for 4 hours. They receive a standard meal 2 hrs before bedtime. They sleep for 8 hrs in the dark (1 lu

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age 18-50 years - male sex - BMI 18-25 - fasting plasma glucose

Exclusion criteria

Exclusion criteria: - medication interfering with glucose metabolism or neuronal synaptic transmission (corticosteroids, anti-depressants, anti-epileptic medication, other psychotropic drugs, anti malarials) - gastro-intestinal or metabolic disease that will interfere with digestion or metabolism - neuropsychiatric illness including severe depression - epilepsy - hypertension - ophthalmological abnormalities - lactose intolerance - soy allergy

Design outcomes

Primary

Measure	Time frame
Postprandial glucose excursions, and expression of metabolic genes in adipose tissue.	—

Secondary

Measure	Time frame
postprandial insulin excursions - postprandial free fatty acid (FFA) excursions - postprandial triglyceride levels - morning glucocorticoid increase - morning salivary melatonin decrease - resting energy expenditure (REE) - measurements of autonomic balance: - skin temperature decrease - heart rate variability	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)