conduct disorder - antisocial behavior
Conditions
Interventions
one group (n=25) receives Methylphenidate (0.3-0.4mg/kg) in capsules of 5mg.
one group (n=25) receives a placebo in the same amound of capsules as the
Methylphenidate group
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: DBD: Subject is diagnosed with ODD (oppositional defiant disorder) and/or CD (conduct disorder). The diagnosis will be confirmed by a standardized psychiatric interview (DISC). HC:IQ, SES and age similar to an adolescent in the basic condition. SES in the same category, IQ in a range of 5 points and age in a range of 1 month.
Exclusion criteria
Exclusion criteria: DBD: Intraocular shreads of metal. Cardiac pacemaker, metal arterial clips, cochlear implant, implanted heart-valves, other implants or metal objects in the body (e.g. non-removable body piercings) not compatible with magnetic fields . Use of medication effecting brain functioning, except for methylphenidate that can be stopped during the day of scanning and the two days before. Pervasive developmental disorder, Tourette*s syndrome, current or lifetime history of psychosis, neurologic disorder, history of head trauma, actual steroid use an IQ less than 80. Contraindications for the use of Methylphenidate. (see protocol page 22) HC: Standard exclusion criteria (NIH) for MRI are the presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body. Contra-indications for using methylphenidate (see page 22). ODD, CD, ADHD, Pervasive developmental disorder, Tourette*s syndrome, current or lifetime history of psychosis, neurologic disorder, history of head trauma, actual steroid use an IQ less than 80. A history of serious antisocial behavior. Use of psychotropic medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differental BOLD-response in the fear conditioning brain network during (reversal) fear conditioning and during reward/punishment sensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Fear conditioning level (CS+ vs CS- differentiation in skin conductance level, pupil dilatation, self-reported arousal and emotional valence). - Reward/punishment sensitivity (reaction time). - Risk taking behavior (number of pumps in risk taking behavior task). - Connectivity between brain structures known to be involved in fear conditioning and reward and punishment through Diffusion Tensor Imaging (DTI) techniques and resting-state fMRI (e.g. amygdala and ventromedial prefrontal cortex) and their structure through structural MRI. | — |
Countries
Netherlands
Outcome results
None listed