Early detection of carcinoma in situ of the testis with a new non-invasive method.

Early detection of carcinoma in situ of the testis with a new non-invasive method. - ScreenCIS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39915

Enrollment

403

Registered

2009-10-12

Start date

2010-01-05

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinoma in situ pre-stage testicular cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Men of 18 years and older with: - Patientgroup 1: riskfactors for TGCT - Patientgroup 2: riskfactors for TGCT and testicular microcalcifications - Controlegroep 1: normospermia and no riskfactors for TGCT - Controlegroep 2: proven fertility

Exclusion criteria

Exclusion criteria: - Men

Design outcomes

Primary

Measure	Time frame
- Reproductive hormones; FSH, LH, testosterone and Inhibin-B - DNA-isolation from blood: identification of TGCT risico SNPs - Semen analysis; volume, concentration, number, motility and pH - Semen diagnostic on the presence of OCT3/4 immunohistochemistry - Semen diagnostic on the presence of TGCT miRNA - Andrological history / Andrological history through web-based questionnaire - Physical examination of the scrotum - Scrotal ultrasound - Testis biopsy	—

Measure

Time frame

- Reproductive hormones; FSH, LH, testosterone and Inhibin-B - DNA-isolation from blood: identification of TGCT risico SNPs - Semen analysis; volume, concentration, number, motility and pH - Semen diagnostic on the presence of OCT3/4 immunohistochemistry - Semen diagnostic on the presence of TGCT miRNA - Andrological history / Andrological history through web-based questionnaire - Physical examination of the scrotum - Scrotal ultrasound - Testis biopsy

—

Countries

Netherlands

Outcome results