Interoceptive fear conditioning and generalization to respiratory sensations in panic disorder patients and healthy controls

Interoceptive fear conditioning and generalization to respiratory sensations in panic disorder patients and healthy controls - Interoceptive fear and generalization

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39913

Enrollment

Registered

2013-09-09

Start date

2013-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety disorder panic disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Panic patients and healthy volunteers aged between 18-65 years and in a good physical condition

Exclusion criteria

Exclusion criteria: • History of pulmonary disease (including asthma and lung fibrosis) • History of cardiovascular disease (including cardiac failure, suspicion of infarct, cardiomyopathy, transient ischemic attack (TIA), angina pectoris, arrythmias) • Hypertension (diastolic > 100; systolic > 170) • Personal or familial history of cerebral aneurysm • Pregnancy • Epilepsy

Design outcomes

Primary

Measure	Time frame
Primary output will be the measures of fear learning to the CS including: the skin conductance response, a potentiated startle blink (EMG), respiration, electrocardiography and self-reported expectancy of the US. The questionnaires (e.g. ASI, PAS, FQ, CLQ, STAI, fear of suffocation) and autobiographical memory will be secondary output variables. A third output variable is the measurement of heart rate variability at rest, derived from a 10 min ECG prior to the experiment.	—

Measure

Time frame

Primary output will be the measures of fear learning to the CS including: the skin conductance response, a potentiated startle blink (EMG), respiration, electrocardiography and self-reported expectancy of the US. The questionnaires (e.g. ASI, PAS, FQ, CLQ, STAI, fear of suffocation) and autobiographical memory will be secondary output variables. A third output variable is the measurement of heart rate variability at rest, derived from a 10 min ECG prior to the experiment.

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Countries

Netherlands

Outcome results