Mechanisms of disability in MS patients with long disease duration

Mechanisms of disability in MS patients with long disease duration - LTD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39903

Enrollment

160

Registered

2011-01-20

Start date

2011-04-08

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MS Multiple sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: *- Male and female subjects aged 18-80 years. *- Diagnosis of either RRMS or SPMS or PPMS at the time of their assessment (defined by Lublin-Reingold criteria) *- A disease duration (from CIS onset) of 15 years or more. - Written informed consent.

Exclusion criteria

Exclusion criteria: - *Pregnancy *- Patient received a course of steroids or had a relapse within the preceding month. *- HIV or other immunodeficiency syndrome. *- History of substance abuse (drug or alcohol) in the past five years *- Specific MRI findings (tumor, subdural haematoma, post-contusional changes, stroke, neurodegenerative disorder, or other relevant MRI finding that could interfere with evaluation) *- Patients unable to undergo MRI.

Design outcomes

Primary

Measure	Time frame
MRI parameters (brain volume, lesion load) OCT parameters (retinal nerve fibre layer thickness in µm) Clinical parameters (EDSS score, MSFC score)	—

Secondary

Measure	Time frame
Questionnaires (concerning diability, depression, fatigue) Neuropsychological parameters (cognitive impairment)	—

Countries

Netherlands

Outcome results