Rabies
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: > 18 years of age
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of vaccinees with RVNA's >0.5 IU/mL. Measurement of Virus neutralizing antibodies: Rabies virus neutralising antibodies (RVNAbs) will be determined in all blood samples by the rapid focus fluorescent inhibition assay (RFFIT), performed in the Erasmus Medical Centre in Rotterdam, the Netherlands. The RFFIT is currently the reference method, prescribed by the WHO. Briefly, a constant dose of previously titrated, cell culture adapted, challenge virus is incubated with serial dilution of the sera to be titrated. A reference serum of known titer is included in each test. The estimation of the percentage of infected cells for each dilution of the sera allows determination of the titer of the unknown sera by comparing with the reference serum. Titers of sera are expressed as International Units per milliliter (IU/ml). Sera with titers *0.5 IU/ml, the WHO recommended protective level, are considered as positive. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events follwong intradermal vaccination | — |
Countries
Netherlands
Outcome results
None listed