Persoonlijkheidsstoornis (psychopathie) psychopathy
Conditions
Interventions
Procedures on both days are identical and consist of an explanation of the
tasks to be performed, the intranasal administration of either placebo or OT
followed by neuropsychological tests displayed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - MALE SEX;;- DIAGNOSIS OF PSYCHOPATHY ACCORDING TO PSYCHOPATHY CHECKLIST - REVISED;;- GOOD PHYSICAL HEALTH;;- AGE BETWEEN 18 AND 60;;- NORMAL OR CORRECTED TO NORMAL VISION; ;- INTELLIGENCE NO LESS THAN BORDERLINE INTELLCTUAL FUNCTIONING.
Exclusion criteria
Exclusion criteria: - OVERSENSITIVITY FOR OXYTOCIN OR CARRIER;;- COLOUR BLINDNESS;;- ILLITERATE OR INSUFFICIENT KNOWLEDGE OF DUTCH LANGUAGE;;- USE OF SSRI'S, MOOD STABILIZERS (E.G. LITHIUM), ANTIPSYCHOTICS OR HORMONAL TREATMENT FOR LIBIDO INHIBITION;;- USE OF ALCOHOL OR RECREATIONAL DRUGS WITHIN LAST 24 HOURS;;- CURRENT PSYCHOTIC DISORDER;;- CURRENT SEVERE DEPRESSIVE DISORDER;;- CURRENT SEVERE ANXIETY DISORDER;;- COMMON COLD WITH SEVERE RUNNING NOSE, CURENTLY OR WITHIN PREVIUOS SEVEN DAYS;;- HISTORY OF NEUROLOGICAL TREATMENT OF BRAIN STRUCTURES OR CURRENT NEUROLOGICAL TREATMENT;;- HISTORY OF ENDOCRINOLOGICAL TREATMENT OR CURRENT ENDOCRINOLOGICAL TREATMENT;;- HISTORY OF SEVERE CLOSED HEAD INJURY WITH LOSS OF CONSCIOUSNESS >15 MINUTES;;- PATIENT'S LEGAL INCAPACITY.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Reading the Mind in the Eyes Test (Baron Cohen, 2001); - Subjective feelings of affective empathy on a Visual Analogue Scale, conform the Multifaceted Empathy Test (MET; Dziobek et al., 2008); - Facial electromyographic (EMG) mimicry recording of the zygomaticus major and the corrugator supercilii muscle activity, following basic emotion inducing film fragments, | — |
Secondary
| Measure | Time frame |
|---|---|
| The equilibrium of the parasympathetic and sympathetic nerve system will be measured in terms of heart rate, respiration and skin conductance; Saliva sampling before and after test procedures, reflecting baseline functioning of the HPA-axis (cortisol) and HPG-axis (testosterone and estradiol). | — |
Countries
Netherlands
Outcome results
None listed