Febrile neutropenia neutropenic fever
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients >= 18 years - Neutropenia due to chemotherapy given for haematological disease or conditioning regimen for autologous or allogenic stem cell transplantation. Neutropenia is defined as absolute neutrophil count 38.3°C once or >= 38.0 °C longer than 1 hour) not related to administration of blood products or medication - Written informed consent
Exclusion criteria
Exclusion criteria: - Patients with a known focus of infection unrelated to the lower respiratory tract - Patients with a history of probable or proven invasive mould infection without a clinically available normalized chest CT and who use antimycotics - Previous participation in the study - Concomitant participation in a study in which the subject is exposed to X-rays - Chest X-ray made on ward (*bed-thorax*)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are chest X-ray, ultra low-dose CT, HRCT and consensus diagnosis. The main endpoint is sensitivity of imaging test for a pulmonary focus of febrile neutropenia as established by consensus diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints are routinely obtained serum galactomannan test, bronchoalveolar lavage (BAL) and blood tests. | — |
Countries
Netherlands
Outcome results
None listed