Non-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophy

Non-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophy - Skeletal muscle MRI in DMD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39843

Enrollment

Registered

2009-07-08

Start date

2009-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duchenne Muscular Dystrophy

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: DMD patients of 8 years and older with typical muscle weakness and a known genetic mutation in the dystrophin gene. Healthy boys of 8 years or older form the control group.

Exclusion criteria

Exclusion criteria: General exclusion criteria are: - Claustrophobia - Pacemakers and defibrillators - Nerve stimulators - Intracranial clips - Intraorbital or intraocular metallic fragments - Cochlear implants - Ferromagnetic implants (e.g. thoracic implant for scoliosis) - Inability to lie supine during less than 60 minutes;Exclusion criteria for healthy controls - any muscle disease - recent muscle trauma

Design outcomes

Primary

Measure	Time frame
Quantitative assessment of pathological changes in skeletal muscle of DMD patients by assessment of: - the level of fatty infiltration - T2 relaxation parameters as a marker for muscle edema - individual muscle volume	—

Secondary

Measure	Time frame
Variation of MR parameters between different muscles, or between different ages in DMD patients. Correlation of MR parameters with strength measurements. Differences of T2 relaxation parameters between steroid users and non-steroid users Explore the use of other MR muscle parameters like diffusion tensor imaging.	—

Countries

Netherlands

Outcome results