Epilepsy seizure disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Children with epilepsy: - Patients between 6 to 17 years of age - Established diagnosis of epilepsy - Mean seizure frequency of at least 1 seizure a year Healthy controls: - Age and gender matched to a child with epilepsy that is included in the study, not diagnosed with any chronic disease
Exclusion criteria
Exclusion criteria: o In patients with epilepsy: -Any doubt about the diagnosis epilepsy -No distinction possible between (co-existing) seizures of (possible) non-epileptic origin and epileptic seizures by parents and/or treating paediatric neurologist - Seizure free since brain surgery or brain surgery scheduled in the following months - Reported status epilepticus in response to acute stress;in total study population: - Children with assessed or expected (based on school level) intelligence quotient (IQ) or IQ estimate (calculated from developmental age) 10 cigarettes a day) -Heavy alcohol consumption (> 60g a day)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcome is the difference in maximum level of cortisol during the Trier Social Stress Test between children with stress sensitive seizures, children with non stress sensitive seizures and healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secundary study parameters are the differences in: - diurnal cortisol variability; - hippocampal function; and - genetic polymorphisms between children with stress sensitive seizures, children with non stress sensitive seizures and healthy controls. | — |
Countries
Netherlands
Outcome results
None listed