Qualitative imaging of cartilage and bone in end stage knee osteoarthritis treated with knee joint distraction or high tibial osteotomy.

Qualitative imaging of cartilage and bone in end stage knee osteoarthritis treated with knee joint distraction or high tibial osteotomy. - Qualitative imaging of OA upon KJD or HTO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39812

Enrollment

Registered

2012-02-07

Start date

2012-06-06

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

joint degeneration osteoarthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients randomized to Knee joint distraction or High tibial osteotomy in either of the two recently started trials.

Exclusion criteria

Exclusion criteria: Patients with risks due to the magnetic field of the MRI such as those with pacemakers, nerve stimulators, metal implants, stents, clips, etc Patients with a known anaphylactic reaction to gadolinium or related substances Patients with (a history of) kidney disease or with a kidney transplantation Patients with a glomerular filtrationrate of

Design outcomes

Primary

Measure	Time frame
The following parameters will be compared between pre-, 1 year, and 2 years post treatment for KJD and pre- and 2 years post treatment for HTO: 1. the change in cartilage proteoglycan content 2. the change in collagen content/distribution 3. the change in bone marrow lesions 4. the change in 3D bone density And secondary: 1. is there a mutual relation between quantitative cartilage and bone changes 2. is there a relation between qualitative cartilage and bone changes with those of quantitative changes in the cartilage as measured in the original RCTs. 3. is there a relation of (combinations of) changes in qualitative and quantitative parameters of bone and cartilage to clinical benefit of KJD and HTO	—

Measure

Time frame

The following parameters will be compared between pre-, 1 year, and 2 years post treatment for KJD and pre- and 2 years post treatment for HTO: 1. the change in cartilage *proteoglycan content* 2. the change in *collagen content/distribution* 3. the change in *bone marrow lesions* 4. the change in *3D bone density* And secondary: 1. is there a mutual relation between quantitative cartilage and bone changes 2. is there a relation between qualitative cartilage and bone changes with those of quantitative changes in the cartilage as measured in the original RCTs. 3. is there a relation of (combinations of) changes in qualitative and quantitative parameters of bone and cartilage to clinical benefit of KJD and HTO

—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results