Borrelia infection Lyme disease
Conditions
Interventions
The participants in the treatment group will take a single dose of doxycycline
in a dosage of 200 mg for adults and children of 8 years and older and above 50
kg body weight
in a dosage of 4 mg/kg doxycycline for children of 8 years and
older and below 50 kg body weight.
Sponsors
RIVM
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Persons who: - are 8 yrs and older - are not pregnant - report a recent tick bite on the webportal Tekenradar.nl * i.e. at the moment of inclusion they are able to take prophylaxis within 72 hrs after removal of the tick. - are willing to send the tick to the RIVM.
Exclusion criteria
Exclusion criteria: Persons who: - are unable to give informed consent or do not have a thorough command of the Dutch language. - report other tick bites in the three months before inclusion. - have a contra indication for treatment with doxycycline (including pregnancy and earlier allergic reactions to tetracyclines). - are * at the moment inclusion * not able to take prophylaxis within 72 hours after removal of the tick
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the prophylaxis efficacy, i.e. the relative risk (RR) reduction for developing Lyme disease after a tick bite and the NNT to prevent one case of Lyme disease. The tick screening results will be used to assess the reduction in NNT when only prescribing prophylaxis if the tick is infected and the engorgement or attachment time are above a certain threshold. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of participants that develop AEs in the month after taking the prophylaxis. Scores for epidemiological risk factors for acquiring tick bites and developing Lyme disease such as exposure to ticks in daily life, participants* activities when acquiring the tick bite, area of acquiring the tick bite, prevention of tick bites. Differences in NNT for children and adults. | — |
Countries
Netherlands
Outcome results
None listed