Acute Effect of Beta-Guanidinopropionic Acid and Creatine in Healthy Men; a Randomized, Placebo-Controlled, Double-Blind, Double-Dummy Study.

Acute Effect of Beta-Guanidinopropionic Acid and Creatine in Healthy Men; a Randomized, Placebo-Controlled, Double-Blind, Double-Dummy Study. - Acute effect of beta-guanidinopropionic acid and creatine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON39788

Enrollment

Registered

2013-11-25

Start date

2014-03-27

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

het onderzoek is niet van toepassing op een klasse van aandoening(en), maar op fysiologische veranderingen gelijkend op het effect van duurtraining. not applicable

Interventions

GPA 100mg versus creatine 5 g and placebo

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy male volunteers, 18-50 years old, non-obese body mass (BMI 18.5-29.9 kg/m2)

Exclusion criteria

Exclusion criteria: BMI>/= 30 kg/m2, diabetes mellitus, lipid spectrum abnormalities, thyroid, kidney, or liver abnormalities, (history of) cardiovascular disease including TIA and stroke; high blood pressure or the use of antihypertensive drugs at baseline; CK-increasing drugs including statins; use of acetylsalicyl acid or non-steroidal anti-inflammatory drugs (NSAIDs) in the two week prior to the visits; neuromuscular or endocrine disorders; vasculitis; HIV infection; infectious hepatitis; personal or family history of bleeding disorders; sickle cell anaemia or other hereditary anaemia; smoking; vegetarian diet; current urse or use within 2 months prior to start of the trial of beta-guanidinopropionic acid or creatine. The participants are instructed not to perform exercise thee days prior to the basline visit and during the study

Design outcomes

Primary

Measure	Time frame
Tolerability of GPA	—

Secondary

Measure	Time frame
The difference in hemodynamic parameters with GPA 100 mg vs placebo and creatine 5 g, including blood pressure, heart rate, cardiac output, and total peripheral resistance. The difference in biochemical parameters with GPA 100 mg vs placebo and creatine 5 g, including serum GPA, creatine, creatine kinase, glucose, insuline, and creatinine, and urine GPA, creatine and creatinine. The difference in ADP-dependent plateletaggregation and thrombocyt count.	—

Measure

Time frame

The difference in hemodynamic parameters with GPA 100 mg vs placebo and creatine 5 g, including blood pressure, heart rate, cardiac output, and total peripheral resistance. The difference in biochemical parameters with GPA 100 mg vs placebo and creatine 5 g, including serum GPA, creatine, creatine kinase, glucose, insuline, and creatinine, and urine GPA, creatine and creatinine. The difference in ADP-dependent plateletaggregation and thrombocyt count.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)