Het betreft fundamenteel onderzoek naar de consolidatie van het langetermijngeheugen in gezonde vrijwilligers, met mogelijke therapeutische relevantie voor populaties met geheugenproblemen zoals ouderen en/of patienten met geheugenstoornissen Long-term memory memory consolidation
Conditions
Interventions
Two experimental groups participate in high intensity physical exercise and a
control session after performing an associative memory task. Experimental
groups differ only in the order of experimenta
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age: 18-28 - Normal or corrected-to-normal vision - Willingness and ability to sign informed consent - Healthy - Performs regular exercise (1-5 times a week) - Body Mass Index between 18.5 and 25 kg/m2
Exclusion criteria
Exclusion criteria: - Subjects that are or might be pregnant - Subjects that use (prescribed) medication, except for paracetamol and oral contraceptives - Subjects that are unable to perform bicycle exercise - Subjects that suffered from recent illness (in past 2 weeks before the day of screening) - Subjects with hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg) - Subjects with any cardiovascular abnormality in current or past medical history or that show such abnormality during the ECG screening. - Subjects with any neurological disorder in current or past medical history. - Subjects with diagnosed diabetes mellitus - Subjects with diagnosed hypercholesterolemia - Subjects who smoke, or who quit smoking less than 2 years ago - Subjects with parents, children and/or siblings who died at a young age (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At the behavioural level, the primary study parameter is the memory performance on the associative memory task (number of correctly recalled associative memories). This is measured directly after learning and after a 2 day delay to check long-term memory retention. The main study parameter is the memory retention, i.e. the difference between memory performance before and after the physical exercise intervention. We aim to investigate how post-learning exercise modulates long-term memory performance. | — |
Secondary
| Measure | Time frame |
|---|---|
| At the neural level, the secondary study parameters are the neural activation and functional connectivity of memory-related brain regions during memory retrieval after the intervention. Before and after both experimental conditions saliva will be obtained from all subjects. By measuring the concentration of cortisol and alpha-amylase in saliva, the physiological effects of exercise can be demonstrated in the subject population. During the intervention subjects will repeatedly report on their subjective experience of the exercise intensity level. In addition, heart rate will be monitored continuously. Finally the participants' activity and sleep rhythm will be recorded with actigraphs in the period between the first and second experimental day as a control measure. | — |
Countries
Netherlands
Outcome results
None listed