Cryopreservation of prepubertal testicular tissue for future autologous transplantation of spermatogonial stem cells: preserving fertility in young boys with cancer

Cryopreservation of prepubertal testicular tissue for future autologous transplantation of spermatogonial stem cells: preserving fertility in young boys with cancer - Cryopreservation of spermatogonial stem cells in childhood cancer patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39737

Enrollment

150

Registered

2009-09-07

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Young patients with cancer (up till 15 years of age) - Scheduled to undergo cytotoxic treatment with risk of future infertility - Unable to produce spermatozoa containing semen

Exclusion criteria

Exclusion criteria: - Malignancies located in the testis (suspicion of metastases of for example lymphomas) - history of bilateral cryptorchidism or testicular torsion - ability to ejaculate vital spermatozoa.

Design outcomes

Primary

Measure	Time frame
Successful sampling and storage of testicular tissue (cryosurvival of SSCs, ability to propagate SSCs in vitro).	—

Secondary

Measure	Time frame
Long-term follow-up of possible side-effects of the testicular biopsy in the boy (local defects, endocrine and exocrine function of the remaining testis), post-pubertal fertility (as determined by semen analysis).	—

Countries

Netherlands

Outcome results