The relevance of donorspecific memory B cells in immunised kidney transplant recipients

The relevance of donorspecific memory B cells in immunised kidney transplant recipients - Donorspecific memory B cells in kidney transplantation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39729

Enrollment

120

Registered

2013-04-02

Start date

2013-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orgaantransplantatie End-stage renal failure kidney transplantation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Kidney transplant recipients who receive a kidney transplant after having rejected their previous transplant. Additionally, thier kidney donors in case of living donor transplantation.

Exclusion criteria

Exclusion criteria: Subjects infected with HIV or Hepatitis C

Design outcomes

Primary

Measure	Time frame
The main parameter to be assessed in the current study is the frequency of donor-specific memory B cells as determined by a novel ELISPOT based technique. Furthermore, donor-specific antibody levels will be determined by CDC and Luminex techniques.	—

Secondary

Measure	Time frame
The secondary study parameters are clinical parameters. The transplant function at 6 and 12 months will be determined by using the estimated Glomerular Filtration Rate (eGFR). Furthermore, the occurence of cellular and antibody mediated rejection within the first year after transplantation will be recorded,	—

Countries

Netherlands

Outcome results