neuropyschiatric syndroms CNS involvement in SLE Neuropsychiatric Systemic Lupus Erythematosus
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Men and women of 18-65 years: NPSLE patients diagnosed in our outpatient clinic with diffuse neurological complaints, SLE patients without neuropsychiatric complaints and Healthy subjects, without cerebral or central nervous system disease, SLE or other chronic inflammation in the body. All volunteers should be competent to give a written informed consent.
Exclusion criteria
Exclusion criteria: -Younger than 18 -Pregnancy -Routine MRI contraindication for 3T and 7T scanners: cardiac pacemaker and defibrillator, vascular clips of the cerebral vessels, nerve stimulators, intraorbital or intraocular metallic fragments, cochlear implants, ferromagnetic implants, hydrocephaluspump, intra-uterine device, iron wire behind the teeth, permanent make-up, piercings or other metal objects that cannot be removed (fillings are allowed) and claustrophobia. - Severe physical restriction (completely wheelchair dependent)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the quantification and localization of microstructural changes in the brain tissue due to NPSLE observed through MRI tools. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameter is characterization of the mechanisms causing the microstructural changes. | — |
Countries
Netherlands
Outcome results
None listed