bloodstream infection sepsis
Conditions
Interventions
None listed
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Main study: -Age > 18 years. -At least one proven episode of mediastinitis/endocarditis/neutropenic bacteremia. -Proven mediastinitis/endocarditis/neutropenic bacteremia according to predefined criteria. -To avoid population stratification only patients with a Caucasian background can be included.;Controls: -Age > 18. -Previous high dose chemotherapy or cardiothoracic surgery, -No infections with gram-positive micro-organisms. -To avoid population stratification only patients with a Caucasian background can be included.;Sub-study: -Age > 18 years. -High dose chemotherapy as a treatment for acute leukemia or prior to an autologous stem cell transplantation OR cardiothoracic surgery with a median sternotomy, in which an extracorporeal circuit is used. -To avoid population stratification only patients with a Caucasian background can be included.
Exclusion criteria
Exclusion criteria: Main study: -Previous thoracic radiotherapy. -Emergency cardiothoracic surgery. -Re-thoracotomy.;Sub-study: -Active infection at the time of or within two weeks before blood sampling. -Current use of antibiotics or antibiotic use within two weeks before blood sampling. -MBL and/or FCN deficient genotype. -Neutropenia at the time of blood sampling, defined as an absolute neutrophil count
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primarily studied endpoint is the difference between the frequency of MBL and FCN SNPs in patients with and without a history of gram-positive bacteremia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the change in MBL en FCN circulating levels before and after cardiothoracic surgery and before and after high dose chemotherapy. | — |
Countries
Netherlands
Outcome results
None listed