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Effects of radiation therapy on oral mucosa microcirculation in patients with malignant disease in the head and neck region.

Effects of radiation therapy on oral mucosa microcirculation in patients with malignant disease in the head and neck region. - Response of oral microcirculation to irradiation.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON39703
Enrollment
20
Registered
2012-11-01
Start date
2013-06-25
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bloeddoorstroming in de microvaten inflammation of oral mucous membrane. oral mucositis

Interventions

None listed

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Patients receiving radiotherapy with curative intent in the Department of Radiotherapy in The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital in Amsterdam * Histology proven squamous cell carcinoma of the oropharynx and oral cavity. * Informed consent from each participating patient. * Patients older than 18 years.

Exclusion criteria

Exclusion criteria: * Patients receiving other cancer treatment besides radiotherapy: systemically (e.g. chemotherapy) or in the area that will be measured (e.g. surgery). * Patients with insulin-dependent diabetes. * Patients that did not sign informed consent * Patients younger than 18 years

Design outcomes

Primary

MeasureTime frame
- capillary enumeration (i.e. counting of the capillary loops present in each visual field). From 5 captured video frames an average will be computed and recorded to represent the capillary density. - a close observation will be made of the morphology of the capillaries. Because we do not know what to expect here, this will be noted discriptively afterwards.

Secondary

MeasureTime frame
-

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)