ejaculatory dysfunction premature and delayed ejaculation
Conditions
Interventions
The intervention entails mild stimulation of the glans penis. Stimulation will
occur in a standardized way, and is not aimed to induce feelings of sexual
arousal in he subject. Stimulations will be
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria (Male Subject: M / Female Partner: F) • 18 years or older (but not over 65): M+F • Involved in a sexual relationship for at least six months: M+F • Signed informed consent: M+F • Cooperative, able to follow instructions: M+F • capable of lying still: M • Normal hand function: F • Heterosexual: M ;Subject inclusion for phase 2 (fMRI experiment) on basis of sexological assessment • Men with IELT 15 min & significant subjective complaints (assigned to RE group) • Men with IELT 2-6 min & no significant complaints (assigned to Healthy group) • Free plasma testosterone within normal range (12-26 nmol/l) • No history of sexual abuse
Exclusion criteria
Exclusion criteria: General exclusion criteria (Male Subject: M / Female Partner: F) • MRI contraindications (specified for M and F in separate questionnaire) • outside normal range on personality questionnaire: M+F • Any psychiatric, somatic or neurological disorders which may affect the Central Nervous System or influence study outcome: M • Claustrophobia, or difficulty in having head restrained: M • Poor motor control, or any condition that interferes with precise hand movements: F • Receiving treatment for ejaculatory complaints: M • Penile circumcision: M • Pregnancy or the possibility to be pregnant: F;Criteria leading to exclusion on the day of the fMRI experiment • When subjects report to have ejaculated in the 24hr prior to the fMRI experiment • When subjects report recreative drug intake (e.g. cocaine, marihuana, ecstacy) in the last two weeks prior to the fMRI experiment • When subjects report alcohol intake in the 24hr prior to the fMRI experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are changes in brain (so-called BOLD) responses to penis stimulation and pelvic floor contraction, and structural brain information about white matter density (so-called fractional anisotropy, FA) provided by the DTI scans. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints: Behavioural and genetic differences between groups and their relation to the measured BOLD response and white matter signal. | — |
Countries
Netherlands
Outcome results
None listed