Veroudering aging elderly
Conditions
Interventions
During the experiment participants undergo TMS and peripheral nerve
stimulation, while they are standing in different postures.
These different postures are:
- Leaning forward 80% of the maximum wit
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Young group: (1) Age 18 - 35 years ;Older group: (1) Age 65 years or older
Exclusion criteria
Exclusion criteria: (1) Neurological disorders (2) Not able to stand independently for 10 minutes without rest (3) Pro-epileptogenic medications or medications known to affect balance (4) Epilepsy (5) Any metal in the brain/skull (6) Pregnancy or suspicion of pregnancy (self-reported)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the size of the short-interval intracortical inhibition (SICI), the amount of EMG suppression after subthreshold TMS and Hmax/Mmax ratio. SICI is the inhibition of the test motor evoked potential (MEP), when the suprathreshold TMS pulse (the test stimulus) is preceded by a few milliseconds with a subthreshold TMS pulse (the conditioning stimulus). SICI and EMG suppression are measures of motor cortical inhibition, and can thus be used to examine cortical influences. The Hmax/Mmax ratio, on the contrary, is a measure of the spinal influences. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters is the Multiscale Entropy (MSE) complexity index of the CoP. | — |
Countries
Netherlands
Outcome results
None listed