allergic esophagitis Eosinophilic esophagitis
Conditions
Interventions
Exclusion diet based on allergy test
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Previous clinical diagnosis of EoO confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid- or proximal-oesophageal biopsies * (Cross-)sensitization against at least 1 food allergen as measured by ImmunoCAP ISAC * Age 18-75 years * Written informed consent
Exclusion criteria
Exclusion criteria: * Inability to stop previously started topical or systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the two month period preceding and during the study * Use of NSAIDs * History of peptic ulcer disease * History of Barrett*s oesophagus * History of GI cancer * History of GI tract surgery (except appendectomy or cholecystectomy) * ASA class IV or V
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oesophageal eosinophilic infiltration at baseline and after dietary treatment, and after reintroduction of foods, as measured by the peak eosinophil count in the oesophageal mucosa. | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms of dysphagia and quality of life (SF-36 and the FAQLQ-AF questionnaire), endoscopic signs of EoO, oesophageal mastocytic infiltration, serum levels of biomarkers for EoO (eosinophil count, total IgE, IL-5, IL-13, eotaxin-3, eosinophil derived neurotoxin [EDN]), oesophageal tissue biomarkers (e.g. IL-5, IL-13, eotaxin-3, periostin, TGF-bèta, filaggrin, phospho-MLCK). Validation of results of the ImmunoCAP ISAC allergy test compared to standard skin prick test results. | — |
Countries
Netherlands
Outcome results
None listed