glucose intolerance Insulin resistance
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Female; BMI > 35 kg/m2; Age between 26 and 50 years; Established T2DM
Exclusion criteria
Exclusion criteria: Primary lipid disorder or secondary lipid disorder treated with fibrates; T2DM treated with thiazolidinediones, DPP4-inhibitors or GLP1-analogues; Any medical condition except for glucose intolerance, hypertension and secondary dyslipidemia; Bleeding disorder; Untreated primary hypothyroidism; Contra-indications for MR scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circulating and tissue levels of RBP4, in relation to: endogenous glucose production; hepatic, peripheral and adipose tissue insulin sensitivity; hepatic triglyceride content | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation levels of RBP4 with hepatic enzymes involved in gluconeogenesis | — |
Countries
Netherlands
Outcome results
None listed