Functional connectivity of cortico-cortical and subcortico-cortical brain networks in Parkinson*s disease

Functional connectivity of cortico-cortical and subcortico-cortical brain networks in Parkinson*s disease - Functional connectivity in PD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON39613

Enrollment

Registered

2008-07-10

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parkinsonism Parkinson's Disease

Interventions

Repetitive transcranial magnetic stimulation (rTMS) will be used to temporarily enhance the excitability of the dorsal prefrontal cortex in patients and, in contrast, to temporarily reduce dorsal re

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: idiopathic PD, 40-65yo

Exclusion criteria

Exclusion criteria: psychotropic medication epilepsy metal in body pregnancy other neurological disease major somatic disorders severe claustrophobia

Design outcomes

Primary

Measure	Time frame
Blood oxygenation level dependent (BOLD) response in dorsal frontal-striatal and cortico-cortical systems in PD patients and controls, compared to their BOLD response as measured during the initial testing session.	—

Secondary

Measure	Time frame
secundary study parameters: 1) Differences in BOLD responses across differnet cognitive and psychiatric symptom-related subgroups in PD patients. 2) Structural abnormalities in PD versus controls, using: a) voxel-based morphometry (VBM): measure for regional volumetry b) diffusion tensor imaging (DTI): measure for structural connectivity 3) Resting state functional connectivity in PD versus controls, focussing on: a) cortico-cortical connections b) cortico-subcortical connections 4) Differences in functional and structural measures between the initial and the current testing session	—

Measure

Time frame

secundary study parameters: 1) Differences in BOLD responses across differnet cognitive and psychiatric symptom-related subgroups in PD patients. 2) Structural abnormalities in PD versus controls, using: a) voxel-based morphometry (VBM): measure for regional volumetry b) diffusion tensor imaging (DTI): measure for structural connectivity 3) Resting state functional connectivity in PD versus controls, focussing on: a) cortico-cortical connections b) cortico-subcortical connections 4) Differences in functional and structural measures between the initial and the current testing session

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)