cardiac dysfunction heart failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients - Women with breast cancer who were treated with chemotherapy and/or radiotherapy in 2006 or before (minimal follow-up period of five years) and after 1970 (due to old fashion treatment or incomplete data) - Written informed consent Controls - Female patients without a history breast cancer, registered in the general practice of the case-patient, matched on age - Written informed consent
Exclusion criteria
Exclusion criteria: Patients and controls - Patients over 80 years of age at the time of diagnosis (because of an expected high frequency of CVD and a life expectancy of less than 10 years in this age-group) - Any history of other cancer (possibility of chemotherapy and / or radiotherapy) - Any history of receiving chemotherapy for other indications - Women who are unable to participate (e.g. terminally or mentally ill)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the proportion of women with a systolic and / or diastolic cardiac dysfunction at echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is heart failure: a combination of clinical complaints and objective abnormalities at physical examination, laboratory examination or echocardiography. | — |
Countries
Netherlands
Outcome results
None listed