Unilaterale letsels one sided physical contstraints Unilateral injuries
Conditions
Interventions
Two groups (groups 1 and 2) will exercise three times per week, six week long.
Subject assigned to the third group will not exercise. Groups 1 and 2 will
perform isometric handgrip contractions of t
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy young adults, age 21 - 35 years, right-handed,
Exclusion criteria
Exclusion criteria: (1) Neurological disorders (2) Pro-epileptogenic medications or medications known to affect balance (3) Epilepsy (4) Any metal in the brain/skull (5) Pregnancy or suspicion of pregnancy (self-reported)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure is the gain in maximal voluntary muscle strength of the untrained wrist flexor muscle group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are, in the left and right wrist flexors, the size of the magnetic brain stimulation produced motor evoked potentials (MEPs), size of the short-interval intracortical inhibition (SICI), size of the maximal compound size of the maximal spinal reflex (M wave) and the size of the spinal excitability, H reflex. MEPs measure corticospinal excitability. SICI is the inhibition of the test MEP when the suprathreshold TMS pulse (the test stimulus) is preceded by a few milliseconds with a subthreshold TMS pulse (the conditioning stimulus) and it is a measure of motor cortical inhibition, and can thus be used to examine cortical influences. The Hmax/Mmax ratio, on the contrary, is a measure of the spinal influences. To address spatial specificity of XED, we also test the force of the left index finger, using a custom built dynamometer (7, 8). Note: Reference numbers correspond with the reference number used in the research protocol. | — |
Countries
Netherlands
Outcome results
None listed