hypertension related. silent brain damage due to elevated blood pressures silent cerebrovascular disease
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria - Patients who participated in the HYBRiD- study - Consent for being contacted for follow-up studies - Essential hypertension: o Use of antihypertensive medication at first visit of the hypertension clinic, or o Office blood pressure: *140 and/ or *90 mmHg (average of 3 measurements with intervals of 2 minutes minimum, or o ABPM blood pressure: *125 and/ or *80 mmHg (average of 24 hours). - Caucasian - Age between 18 and 90 years - Ambulant
Exclusion criteria
Exclusion criteria: - - Cerebrovascular abnormalities in anamnesis o TIA in 6 months before anamnesis o Brain infarction o Haemorrhage (subarachnoid or intracerebral) - Contra indications for MRI o Heart valve prosthesis o Pacemaker o Intracerebral clips (aneurysm) o Intra-ocular metal pieces o Cochlear implant o Claustrophobia - When the patient does not appreciate to receive the results of the study, in particular if abnormalities are found during MRI or neuropsychological assessment, which are of great importance for the patients health.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of SVD (WMLs, LACIs, and BMBs) and cognitive functioning. | — |
Secondary
| Measure | Time frame |
|---|---|
| Haptoglobin polymorphism and EPC-activity. Other cerebral abnormalities observed by MRI: atrophy and other cerebral abnormalities. | — |
Countries
Netherlands
Outcome results
None listed